Journal
VACCINE
Volume 24, Issue 9, Pages 1238-1241Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2005.09.029
Keywords
dengue; vaccine; clinical trial
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We conducted a Phase 1b Study to evaluate the immunogenicity and safety of two live attenuated tetravalent dengue vaccines in healthy adult Volunteers. After one injection, all subjects reported systemic reactions consistent with a mild dengue-like syndrome. Seven volunteers developed dengue 3 viraemia after vaccination. All subjects developed a neutralizing antibody response against serotype 3 with partial response against other serotypes. The trial was stopped early (after 10 subjects enrolled) due to formulation issues, which were related to the dengue 3 vaccine component. Managing viral interference and balancing attenuation to produce acceptable tetravalent immunogenicity with minimal reactogenicity may be a recurring problem for future multivalent live vaccines. (c) 2005 Elsevier Ltd. All rights reserved.
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