Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 12, Issue 3, Pages 248-253Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2005.01340.x
Keywords
bacteriophage therapy; Escherichia coli O157 : H7; in-vivo selection; mice; persistence
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A bacteriophage lytic for Escherichia coli O157:H7 was isolated from bovine manure. Following in-vivo selection, the phage acquired the capacity to persist in the circulatory system of mice for at least 38 days. When mice were infected experimentally with E. coli O157:H7 (10(7) CFU/mouse), simultaneous injection of the mice with phage (10(8) PFU/mouse) cleared E. coli O157:H7 from the mice within 48 h.
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