Journal
LANCET NEUROLOGY
Volume 5, Issue 3, Pages 246-256Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(06)70374-X
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Funding
- NINDS NIH HHS [NS13515, NS42708] Funding Source: Medline
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As in Clark and Prout's classic work, we identify three phases of generalised convulsive status epilepticus, which we call impending, established, and subtle. We review physiological and subcellular changes that might play a part in the transition from single seizures to status epilepticus and in the development of time-dependent pharmacoresistance. We review the principles underlying the treatment of status epilepticus and suggest that prehospital treatment is beneficial, that therapeutic drugs should be used in rapid sequence according to a defined protocol, and that refractory status epilepticus should be treated with general anaesthesia. We comment on our preference for drugs with a short elimination half-life and discuss some therapeutic choices.
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