Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 38, Issue 3, Pages 151-156Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1745-7270.2006.00154.x
Keywords
acyl-CoA; cholesterol acyltransferase; cholesterol; cholesteryl ester; atherosclerosis
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Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. At the single-cell level, ACAT serves as a regulator of intracellular cholesterol homeostasis. In addition, ACAT supplies cholesteryl esters for lipoprotein assembly in the liver and small intestine. Under pathological conditions, the accumulation of cholesteryl esters produced by ACAT in macrophages contributes to foam cell formation, a hallmark of the early stage of atherosclerosis. Several reviews addressing various aspects of ACAT and ACAT inhibitors are available [1-8]. This review briefly outlines the current knowledge on the biochemical properties of human ACATs, and then focuses on discussing the merit of ACAT as a drug target for pharmaceutical interventions against atherosclerosis.
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