Journal
HYPERTENSION
Volume 47, Issue 3, Pages 515-521Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.HYP.0000196268.08909.fb
Keywords
hypertension; receptors, angiotensin; angiotensin converting enzyme; angiotensin II
Categories
Funding
- NHLBI NIH HHS [HL-51952, HL-6835] Funding Source: Medline
Ask authors/readers for more resources
This lecture summarizes the chronology and rationale that led to the discovery of angiotensin-(1-7) as a hormone that, in its own right, opposes the vasoconstrictor and proliferative actions of angiotensin II. The work discussed here additionally analyzes the newest findings on angiotensin- converting enzyme 2, the angiotensin- converting enzyme homologue that efficiently hydrolyzes angiotensin II into angiotensin-(1-7). Both components of this system may significantly influence our future perspective of the role of the renin-angiotensin system, not just in terms of its role in the regulation of cardiovascular and renal function but, moreover, as regulators of a vast array of disease processes in which inflammation and immune mechanisms play a role.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available