Journal
PLOS BIOLOGY
Volume 4, Issue 3, Pages 420-431Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.0040063
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Funding
- NIGMS NIH HHS [T32-GM07526, T32 GM007526] Funding Source: Medline
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Acetylcholine is the major excitatory neurotransmitter in the central nervous system of insects. Mutant analysis of the D alpha 7 nicotinic acetylcholine receptor (nAChR) of Drosophila shows that it is required for the giant fiber-mediated escape behavior. The D alpha 7 protein is enriched in the dendrites of the giant fiber, and electrophysiological analysis of the giant fiber circuit showed that sensory input to the giant fiber is disrupted, as is transmission at an identified cholinergic synapse between the peripherally synapsing interneuron and the dorsal lateral muscle motor neuron. Moreover, we found that gfA(1), a mutation identified in a screen for giant fiber defects more than twenty years ago, is an allele of Da7. Therefore, a combination of behavioral, electrophysiological, anatomical, and genetic data indicate an essential role for the Da7 nAChR in giant fiber-mediated escape in Drosophila.
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