Journal
IMMUNITY
Volume 24, Issue 3, Pages 295-304Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2006.01.014
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI28900] Funding Source: Medline
- NIGMS NIH HHS [R01 GM067159-01] Funding Source: Medline
Ask authors/readers for more resources
Nup98 and Nup96 are components of the nuclear transport machinery and are induced by interferons (IFN). Nup98 is a constituent of an mRNA export pathway that is targeted by viruses and regulated by IFN. However, the role of Nup96 in IFN-related mechanisms has not been established. To investigate the function of Nup96 in vivo, we generated Nup86(+/-) mice that express low levels of Nup96, as Nup96(-/-) mice are lethal. The Nup96(+/-) mice presented selective alterations of the immune system, which resulted in downregulation and impaired IFN alpha- and gamma-mediated induction of MHC I and IFN gamma induction of MHC II, ICAM-1, and other proteins. Frequency of TCR alpha beta+ and CD4+ T cells, which depends on MHC function, is reduced in NUP96(+/-) mice. Upon immunization, Nup96(+/-) mice showed impaired antigen presentation and T cell proliferation. Nup96(+/-) cells and mice were highly susceptible to viral infection, demonstrating a role for Nup96 in innate and adaptive immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available