Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 36, Issue 2, Pages 177-181Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2005.12.018
Keywords
cancer; malignancy; thrombosis; tissue factor; microparticles
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Thrombosis is one of the major complications of malignant disease, but the underlying Molecular and cellular basis remains elusive. A number of hypotheses have been put forth, including the expression of tissue factor by tumor cells, release of tissue factor during cell death following chemotherapy, intrinsic unique tumor procoagulants and microparticles. Exploration of a potential role of microparticles in cancer-associated thrombosis indicates that tissue factor microparticles are present in a spectrum of cancer patients known to have a high incidence of thromboembolic complications. (c) 2006 Elsevier Inc. All rights reserved.
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