Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 206, Issue 3, Pages 807-813Publisher
WILEY
DOI: 10.1002/jcp.20523
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Funding
- NCI NIH HHS [R01 CA60999] Funding Source: Medline
- PHS HHS [P0INS36466] Funding Source: Medline
- Telethon [TCP00081] Funding Source: Medline
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During skeletal myogenesis, muscle-regulatory factors bHLH and MEF2 promote the expression of muscle-specific genes by recruiting several chromatin-modifying complexes on specific DNA regulatory sequences. A number of MyoD-interacting proteins have been reported, but whether they are recruited to the chromatin of myogenic loci, and the relationship with other chromatin bound proteins is unknown. We show that MyoD recruits cdk9/cyclin T2, together with the histone acetyltransferases p300 and PCAF, and the chromatin remodeling complex SWI/SNF, on promoters and enhancers of muscle-specific genes, and that this event correlates with the acetylation of histone tails, remodeling of chromatin, and phosphorylation of the C-terminal domain (CTD) of the RNA polymerase II at these elements. (C) 2005 Wiley-Liss, Inc.
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