Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 36, Issue 2, Pages 99-103Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2005.12.007
Keywords
megakaryocyte; proplatelet; platelet; tubulin; microtubules; dynein; actin; membrane skeleton
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Platelets release from megakaryocytes living primarily in the bone marrow space. Intermediates in platelet formation are proplatelets, long tube-like processes that are extended by microtubule-based forces hundreds of micrometers from the megakaryocyte cell body. Granules and organelles enter the proplatelets and traffic up and down on their microtubules to be ultimately delivered to the platelet buds before they release. How individual platelets form and release from proplatelets remains poorly understood. (c) 2006 Elsevier Inc. All rights reserved.
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