4.5 Letter

Reaction to the paper: Interaction of polysorbate 80 with erythropoietin: A case study in protein-surfactant interactions

Journal

PHARMACEUTICAL RESEARCH
Volume 23, Issue 3, Pages 641-642

Publisher

SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-006-9573-5

Keywords

epoetin; Eprex; immunogenicity; micelles; polysorbate 80

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Micelle-associated epoetin is still a possible explanation for the upsurge of pure red blood cell aplasia associated with subcutaneous use of epoetin alpha in patients with chronic renal failure.

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