Journal
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Volume 131, Issue 3, Pages 671-U65Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jtcvs.2005.09.018
Keywords
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Funding
- NCRR NIH HHS [M01RR02558] Funding Source: Medline
- NHLBI NIH HHS [R01 HL62594, R01 HL09509, R01 HL59249] Funding Source: Medline
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Objective: The histopathologic abnormality underlying ascending aortic aneurysm and dissection is medial degeneration, a lesion that is described as the noninflammatory loss of smooth muscle cells and elastic fibers. This study sought to determine whether inflammatory cells are present in medial degeneration and assess any possible contribution of these cells to apoptosis of smooth muscle cells. Methods: Aortic specimens were obtained from patients undergoing prophylactic surgical repair of an ascending aortic aneurysm ( n = 9) and type A dissection ( n = 7), along with control patients dying of causes unrelated to aortic disease ( n = 5). Immunohistochemical staining was performed to evaluate the presence of lymphocytes and macrophages, and markers of apoptosis were assessed in the aortas of patients with ascending aortic aneurysm and dissection. Results: Immunohistochemical study indicated significantly more CD3(+) cells in the aortas of patients with aneurysms or dissections than in control aortas ( P = .020 and P = .0022, respectively). In addition, aortas of patients with aneurysms or dissections had more CD68(+) cells ( P = .01 and P = .005, respectively). CD3(+) cells were localized in the media and surrounding the vasa vasorum in the adventitia. Cells yielding a positive result on in situ terminal transferase - mediated deoxyuridine triphosphate nick end- labeling were found in increased numbers in the aortas of patients with aneurysms or dissections relative to control aortas ( P = .005 and P = .002, respectively). Furthermore, Fas and FasL were increased in the aortic samples from patients with aneurysms and dissections relative to control aortas. Conclusion: The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aortas with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix associated with thoracic aortic aneurysms and dissections.
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