Journal
NANO LETTERS
Volume 6, Issue 3, Pages 537-542Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl060060o
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Funding
- NHLBI NIH HHS [HL078534] Funding Source: Medline
- NIGMS NIH HHS [GM63283-02] Funding Source: Medline
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Skeletal muscle consists of parallel bundles of myotubes formed by the fusion of myoblasts, We fabricated nanofibrous and micropatterned polymers as cell culture substrates to guide the morphogenesis of muscular tissue. The nanoscale and microscale topographic features regulate cell and cytoskeleton alignment, myotube assembly, myotube striation, and myoblast proliferation, This bottom-up approach from nanoscale to tissue level demonstrates the potential of nanofibrous polymers for engineering the assembly of cell and tissue structure.
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