Journal
INFECTION AND IMMUNITY
Volume 74, Issue 3, Pages 1967-1972Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.74.3.1967-1972.2006
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The binding of Borrelia burgdorferi OspE, OspF, and family 163 (Elp) proteins to factor H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed. OspE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and Elp proteins did not. These data advance our understanding of factor H binding, the host range of the Lyme spirochetes, and the expanding role of OspE in pathogenesis.
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