Left ventricular mass and+276 G/G single nucleotide polymorphism of the adiponectin gene in uncomplicated obesity

The single nucleotide polymorphisin at position 276 in the adiponectin gene (APM1/ACDC + 276 G > T) and left ventricular mass (LVM) have been associated with increased cardiovascular risk. We Sought to evaluate whether +276 G > T variants in the adiponectin gene are correlated with LVM in uncomplicated obese subjects. APM1/ACDC 1 276 G > T single nucleotide polymorphism, echocardiographic indexed LVM (LVM/body surface area and LVM/ height(2.7)), insulin sensitivity by euglycemic clamp, and plasma adiponectin levels were analyzed in 62 obese subjects Without complications (51 women and 11 men: mean age. 34.2 +/- 10.2 bears; BMI, 38.6 +/- 9.1 kg/m(2)). Forty lean subjects formed the control group for LVM evaluation. We found 23 (37%) uncomplicated obese Subjects with the APM1/ACDC+276 G/G genotype, 25 (40%) with the G/T genotype, and 14 (23%) with the T/T Genotype. G/G uncomplicated obese subjects showed significant higher LVM/body, surface area and LVM/height(2.7) (within the formal range in the majority of them) than uncomplicated obese subjects carrying the G/T and T/T genotypes (p < 0.01 and p < 0.05, respectively). This Study showed that LVM is significantly higher in uncomplicated obese subjects carrying the G/G Genotype at position 276 of the human adiponectin gene.