Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 84, Issue 3-4, Pages 299-307Publisher
NATL RESEARCH COUNCIL CANADA
DOI: 10.1139/Y05-158
Keywords
nuclear envelope receptors; angiotensin II; neuropeptide Y; endothelin-1; endocardial endothelial cells; intracellular calcium
Categories
Funding
- NIDDK NIH HHS [DK41301] Funding Source: Medline
Ask authors/readers for more resources
Neuropeptide Y (NPY). endothelin-1 (ET-1). and angiotensin II (Ang II) are peptides that are known to play many important roles in cardiovascular homeostasis. The physiological actions of these peptides are thought to be primarily mediated by plasma membrane receptors that belong to the G-protein-coupled receptor superfamily. However, there is increasing evidence that suggests the existence of functional G-protein-coupled receptors at the level of the nucleus and that the nucleus could be a cell within a cell. Here. we review our work showing the presence in the nucleus of the NPY Y-I receptor. the ETA and ETB receptors, as well as the AT(1) and AT(2) receptors and their respective ligands. This work was carried Out in 20-week-old fetal human endocardial endothelial cells. Our results demonstrate that nuclear Y-I, AT(1), and ETA receptors modulate nuclear calcium in these cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available