Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 54, Issue 3, Pages 355-361Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1369/jhc.5A6734.2005
Keywords
thyroid carcinoma; vitamin D; 1-alpha-hydroxylase; immunohistochemistry RT-PCR
Categories
Ask authors/readers for more resources
Vitamin D receptor (VDR) and 25-hydroxyvitamin D-3 1-alpha-hydroxylase expression have recently been shown to be upregulated in several tumors and thought to represent an important endogenous response to tumor progression. Little is known about the expression of these proteins in thyroid carcinoma, although previous reports have documented evidence of the biological effect of vitamin D in thyroid cells. Using paraffin-embedded and frozen sections of papillary thyroid carcinoma, we utilized real-time quantitative RT-PCR and immunohistochemistry to characterize the expression of VDR and 1-alpha-hydroxylase in thyroid follicular cells, with special emphasis on papillary thyroid carcinoma (PTC). VDR and 1-alpha-hydroxylase expression were increased in PTC compared with normal thyroid tissue and especially high in areas of lymphocyte infiltration. Expression of VDR and 1-alpha-hydroxylase in PTC may be compatible with an overall favorable prognosis for 1 this tumor type and may constitute important prerequisites for using vitamin D and/or vitamin D analogs in the treatment of PTC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available