Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 5, Pages 2575-2577Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.80.5.2575-2577.2006
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Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HRV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD(D/E)XK endonuclease activity in the viral life cycle.
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