Journal
GENETICS
Volume 172, Issue 3, Pages 1595-1605Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.105.048520
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM18818-03, GM45344, F32 GM018818, P01 GM045344] Funding Source: Medline
Ask authors/readers for more resources
Life-history theory and evolutionary, theories of aging assume the existence of alleles with age-specific effects oil fitness. While various Studies have documented age-related changes in the genetic contribution to variation in fitness components, we know very little about the underlying genetic architecture Of Such changes. We used a set of recombinant inbred lines to map and characterize the effects of quantitative trait loci (QTL) affecting fecundity of Drosophila melanogaster females at 1 and 4 weeks of age. We identified one QTL on the second chromosome and one or two QTL affecting fecundity oil the third chromosome, but these QTL affected fecundity only at I week of age. There was more genetic variation for fecundity at 4 weeks of age than at I week of age and there was no genetic correlation between early and late-age fecundity. These results Suggest that. different loci contribute to the variation in fecundity as the organism ages. Our data provide Support for the mutation accumulation theory of aging as applied to reproductive senescence. Comparing the results from this study with our previous work on life-span QTL, we also find evidence that antagonistic pleiotropy may contribute to the genetic basis of senescence in these lines as well.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available