Journal
TRENDS IN MICROBIOLOGY
Volume 14, Issue 3, Pages 132-140Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2006.01.001
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Funding
- NCI NIH HHS [CA 93606, CA 085678] Funding Source: Medline
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Cellular chromatin forms a dynamic structure that maintains the stability and accessibility of the host DNA genome. Viruses that enter and persist in the nucleus must, therefore, contend with the forces that drive chromatin formation and regulate chromatin structure. In some cases, cellular chromatin inhibits viral gene expression and replication by suppressing DNA accessibility. In other cases, cellular chromatin provides essential structure and organization to the viral genome and is necessary for successful completion of the viral life cycle. Consequently, viruses have acquired numerous mechanisms to manipulate cellular chromatin to ensure viral genome survival and propagation.
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