4.7 Article

Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis:: Identification of a novel mutation in inhA

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 50, Issue 3, Pages 1075-1078

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.50.3.1075-1078.2006

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Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.

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