Journal
DEVELOPMENT
Volume 133, Issue 5, Pages 957-966Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02266
Keywords
formin; DAAM; actin cytoskeleton; tracheal cuticle; Src kinases; Drosophila
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Funding
- FIC NIH HHS [TW05893] Funding Source: Medline
- NIGMS NIH HHS [R01 GM62917] Funding Source: Medline
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Formins are involved in a wide range of cellular processes that require the remodeling of the actin cytoskeleton. Here, we have analyzed a novel Drosophila formin, belonging to the recently described DAAM subfamily. In contrast to previous assumptions, we show that DAAM plays no essential role in planar cell polarity signaling, but it has striking requirements in organizing apical actin cables that define the taeniclial fold pattern of the tracheal cuticle. These observations provide evidence the first time that the function of the taenidial organization is to prevent the collapse of the tracheal tubes. Our results indicate that although DAAM is regulated by RhoA, it functions upstream or parallel to the non-receptor tyrosine kinases Src42A and Tec29 to organize the actin cytoskeleton and to determine the cuticle pattern of the Drosophila respiratory system.
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