Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 8, Issue 3-4, Pages 628-638Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2006.8.628
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Funding
- NIA NIH HHS [P01 AG19316, P01 AG20591, P03 AG13319] Funding Source: Medline
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Transgenic mice overexpressing both Cu/ZnSOD and catalase [Tg(SOD1/CAT)(+/o)] were used to evaluate the effects of overexpression of both genes against oxidative stress. Characterization of these transgenic mice revealed that catalase or Cu/ZnSOD activities were two- to fourfold higher in the tissues of transgenic mice compared to wild-type mice, and the activities of the other major antioxidant enzymes were not altered in the tissues of the transgenic mice. The murine embryonic fibroblasts (MEFs) from the Tg(SOD1/CAT)(+/o) and MEFs overexpressing Cu/ZnSOD were more resistant to paraquat cytotoxicity, relative to wild-type MEFs. The MEFs from Tg(SOD1/CAT)(+/o) tended to be more resistant (up to 2.25-fold) to paraquat cytotoxicity than MEFs overexpressing either Cu/ZnSOD or catalase alone. MEFs from Tg(CAT)(+/o) and Tg(SOD1/CAT)(+/o) were equally as resistant to hydrogen peroxide cytotoxicity. However, there were no significant differences in whole animal survival against either paraquat or gamma-radiation.
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