Journal
APPLIED RADIATION AND ISOTOPES
Volume 64, Issue 3, Pages 315-324Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2005.08.003
Keywords
BNCT; boron carbide; B16 melanoma; nanoparticles; TEM; XRD; PCS; XPS; FTIR; gel electrophoresis and ninhydrin
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Boron carbide nanoparticles are proposed as a system for T cell-guided boron neutron capture therapy. Nanoparticles were produced by ball milling in various atmospheres of commercially available boron carbide. The physical and chemical properties of the particles were investigated using transmission electron microscopy, photon correlation spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, vibrational spectroscopy, gel electrophoresis and chemical assays and reveal profound changes in surface chemistry and structural characteristics. In vitro thermal neutron irradiation of B16 melanoma cells incubated with sub-100 nm nanoparticles (381.5 mu g/g B-10) induces complete cell death. The nanoparticles alone induce no toxicity. (c) 2005 Elsevier Ltd. All rights reserved.
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