Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 172, Issue 1-2, Pages 198-205Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2005.11.007
Keywords
autism; cytokines; adaptive immune responses
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This study compared production of IL-2, IFN-gamma, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-gamma/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-gamma/IL-10 than controls. Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10. (C) 2005 Elsevier B.V. All rights reserved.
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