Journal
PATHOLOGIE BIOLOGIE
Volume 54, Issue 2, Pages 100-108Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.patbio.2005.09.001
Keywords
muscle reggeneration; muscular dystrophy; cell-mediated gene therapy; myoblast transplantation; telomeres; stem cell therapy
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Human skeletal muscle has been considered as an ideal target for cell-mediated therapy. However, the positive results obtained in dystrophic animal models using the resident precursor satellite cell population have been followed by discouraging evidences obtained in the clinical trials involving Duchenne muscular dystrophy patients. This text reviews the recent advances that many groups have achieved to identify from the stem cell compartment putative candidates for cell therapy. We focused our attention on stem cells with myogenic potential which might be able to improve transplantation efficiency and therefore could be used as a therapeutic tool for neuromuscular diseases. (C) 2005 Elsevier SAS. All rights reserved.
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