Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 70, Issue 3, Pages 423-427Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2010.139550
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Funding
- European Community
- Dutch Arthritis Association (Reumafonds)
- EULAR Synovitis Study Group
- OMERACT Special Interest Group on Synovial Analysis in Clinical Trials
- NovoNordisk
- Cancer Research UK
- Versus Arthritis [18475] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10299] Funding Source: researchfish
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Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
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