Journal
EPILEPSY & BEHAVIOR
Volume 8, Issue 2, Pages 376-383Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2005.12.009
Keywords
epilepsy; seizures; tien ma; tian ma; Gastrodia elata; Armillaria mellea; drugs; Chinese herbal; antiepileptic drugs; gastrodin; vanillin; gamma-aminobutyric acid
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Our purpose is to bring attention to the antiepileptic properties of the Chinese herb tian ma and its constituents, as well as to suggest the potential for the development of new antiepileptic drugs (AEDs) related to this herb. All available literature regarding the chemistry, pharmacology, animal data, and clinical use of tian ma and its constituents are reviewed, showing that tian ma, its constituents, and its symbiotic fungus Armillaria mellea have antiepileptic properties in in vitro and in vivo models. One clinical study reportedly demonstrated the AED effects of a component of tian ma, vanillin. Thus, tian ma, its constituent vanillin, and its symbiotic fungus armillaria hold promise as cost-effective and less toxic alternatives to standard AEDs. In addition, similar chemical compounds may be developed as AEDs. (C) 2006 Elsevier Inc. All rights reserved.
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