Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine

To elucidate the contribution of human leukocyte antigen ( HLA) haplotypes and their genotypic combinations to immune status after measles-mumps-rubella ( MMR) vaccination, 346 children 12 - 18 years of age were studied. The class I A*29-Cw*16-B*44 haplotype was associated with lower levels of immunoglobulin G ( IgG) antibody to both measles (P = .08) and mumps (P = .03) viral antigens. The A*26-Cw*12-B*38 haplotype was associated with higher cellular immune responses to measles (P = .02) and mumps (P = .01) vaccine viruses. Subjects with the class II DRB1*03-DQB1*02-DPB1*04 haplotype had higher lymphoproliferative responses to measles virus (P = .01) and mumps virus (P = .006). The DRB1*15/16-DQB1*06-DPB1*03 haplotype was associated with high levels of IgG antibody to measles virus () but low levels of IgG antibody to rubella virus (P = .02), whereas DRB1*04-DQB1*03-DPB1*03 was associated with high lymphoproliferative responses to both measles (P = .02) and rubella (P = .002) vaccine viruses. A*26-Cw*12-B*38 was associated with both mumps virus-specific humoral (P = .007) and cell-mediated (P = .01) immune responses after 2 doses of MMR vaccine. Haplotype DRB1*04-DQB1*03-DPB1*03 was associated with both lower rubella virus IgG antibody levels (P = .02) and higher rubella virus-specific lymphoproliferation (P = .002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level.