Journal
NATURE NEUROSCIENCE
Volume 9, Issue 3, Pages 311-313Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1650
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- Intramural NIH HHS Funding Source: Medline
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In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.
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