Journal
NATURE REVIEWS MICROBIOLOGY
Volume 4, Issue 3, Pages 193-200Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1349
Keywords
-
Categories
Ask authors/readers for more resources
Many microbial pathogens, including those responsible for major enteric infections, exploit oligosaccharides that are displayed on the surface of host cells as receptors for toxins and adhesins. Blocking crucial ligand-receptor interactions is therefore a promising therapeutic strategy. One approach is to express molecular mimics of host receptors on the surface of harmless recombinant bacteria that can survive in the gut. These 'designer probiotics' bind bacterial toxins in the gut lumen with very high avidity, thereby preventing disease. This article discusses recent progress with this strategy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available