Journal
BIOMATERIALS
Volume 27, Issue 9, Pages 1679-1687Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2005.11.018
Keywords
biomimetic material; confocal microscopy; fluorescence; molecular imaging; nanoparticle; surface modification
Funding
- NIBIB NIH HHS [5-R01-EB000312, R01 EB000312-06A1, R01 EB000312] Funding Source: Medline
Ask authors/readers for more resources
After much effort in surface chemistry development and optimization by several groups, fluorescent semiconductor nanocrystals probes, also known as quantum dots or qdots, are now entering the realm of biological applications with much to offer to biologists. The road to success has been paved with hurdles but from these efforts has stemmed a multitude of original surface chemistries that scientists in the biological fields can draw from for their specific biological applications. The ability to easily modulate the chemical nature of qdot surfaces by employing one or more of the recently developed qdot coatings, together with their exceptional photophysics have been key elements for qdots to acquire a status of revolutionary fluorescent bio-probes. Indeed. the unique properties of qdots not only give biologists the opportunity to explore advanced imaging techniques such as single molecule or lifetime imaging but also to revisit traditional fluorescence imaging methodologies and extract yet unobserved or inaccessible information in vitro or in vivo. (C) 2005 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available