Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 69, Issue -, Pages 77-82Publisher
B M J PUBLISHING GROUP
DOI: 10.1136/ard.2009.119479
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI070555] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI070555, R01 AI070555-05] Funding Source: Medline
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Despite the success of biological therapies in rheumatoid arthritis (RA), orally active small-molecule drugs are desirable. Signal transduction inhibitors have been the focus of intense efforts, with some recent notable successes and failures. p38 alpha is a signalling molecule that regulates proinflammatory cytokines, which makes it a logical target for RA. Unfortunately, selective p38a inhibitors have limited efficacy. An attempt is made here to put these studies into perspective and offer possible explanations for the failure of p38a blockers. Alternative strategies, such as targeting kinases higher in the signalling cascade or using less selective compounds, might be more successful as suggested by the efficacy seen with Syk and JAK inhibitors.
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