Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 5, Pages 552-564Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5446-z
Keywords
inositol pyrophosphates; signaling; kinase; phosphorylation; metabolism; phytic acid
Categories
Funding
- MRC [MC_U122680443] Funding Source: UKRI
- Medical Research Council [MC_U122680443] Funding Source: Medline
- Medical Research Council [MC_U122680443] Funding Source: researchfish
Ask authors/readers for more resources
Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that have a range of signaling functions. Since the discovery of inositol pyrophosphates in the early 1990s, enormous progress has been achieved in characterising this class of molecules, linking their biological presence to a wide range of cellular functions, including vesicular trafficking, apoptosis, telomere maintenance and protein phosphorylation. The activity of inositol pyrophosphates appears to be related to their rapid turnover in cells and also to their pyrophosphate groups, which are considered to contain high-energy bonds. Together, these observations suggest that inositol pyrophosphates may represent a class of cellular messengers with basic and not yet fully characterised functions. This review aims at summarising the recent progress of our knowledge of this exciting class of molecules, from inositol pyrophosphate discovery to the description of their physiological functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available