Journal
NATURE CELL BIOLOGY
Volume 8, Issue 3, Pages 238-248Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1366
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- NIGMS NIH HHS [GM-56779-02] Funding Source: Medline
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The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose of, Golgi ribbon formation are known. Here, we demonstrate that ribbon formation is mediated by specific membrane-fusion events that occur during Golgi assembly, and require the Golgi proteins GM130 and GRASP65. Furthermore, these GM130 and GRASP65-dependent lateral cisternal-fusion reactions are necessary to achieve uniform distribution of enzymes in the Golgi ribbon. The membrane continuity created by ribbon formation facilitates optimal processing conditions in the biosynthetic pathway.
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