Journal
NEUROLOGICAL SCIENCES
Volume 27, Issue -, Pages S24-S26Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-006-0541-y
Keywords
fMRI; multiple sclerosis; stroke; Alzheimer's disease; brain plasticity
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Functional magnetic resonance imaging (fMRI) is being widely used to study recovery of function in patients with several neurological conditions, including multiple sclerosis, stroke and Alzheimer's disease. The application of this MR technique has shown that plastic cortical changes do occur after central nervous system (CNS) injury of different aetiology, that such changes are related to the extent of CNS damage and that the can contribute in limiting the clinical consequences of brain damage. Conversely, the failure or exhaustion of the adaptive properties of the cerebral cortex might be among the factors responsible for the accumulation of 'fixed' neurological deficits. New studies aimed at investigating the effect of therapies devoted to promote brain plasticity are now warranted.
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