SHP2 forecast for the immune system: fog gradually clearing

The src homology 2 (SH2) domain containing tyrosine phosphatase SHP2 (also referred to as SHP-2) is ubiquitously expressed in mammalian tissues and has been shown to be essential for embryonic development, haematopoiesis and signalling downstream of a variety of growth factors. Dysregulation of SHP2 function or expression has recently been implicated in the pathogenesis of human diseases involving haematopoietic cell lineages. New findings also demonstrate the involvement of SHP2 in the regulation of immune responses through its effects on cytokine and inhibitory receptor signalling pathways, and novel transgenic models are providing valuable insights into the role of SHP2 in T cells.