Journal
ANTIMICROBIAL THERAPEUTICS REVIEWS: INFECTIOUS DISEASES OF CURRENT AND EMERGING CONCERN
Volume 1323, Issue -, Pages 22-42Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12537
Keywords
carbapenem-resistant Enterobacteriaceae; antimicrobial resistance; carbapenemases; molecular genetics; infection control; treatment
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Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug-resistant Gram-negative organisms. Over the last decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.
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