Journal
MATERIALS AND MANUFACTURING PROCESSES
Volume 21, Issue 3, Pages 291-296Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10426910500464727
Keywords
antibiotic solution; biodegradation; cell count; cell growth; cell line; cell morphology; cytotoxicity; fetal bovine serum; hydrolytic degradation; incubation; lactate ester diol; film casting; polyester urethane; tensile strength; trypsinization
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A polyester urethane was synthesized for use in a biodegradable scaffold. The polyurethane was synthesized in a two-step process: first, ester diol was synthesized from lactic acid and polyethylene glycol 400 (PEG 400), then it was polymerized with toluene diisocyanate using dibutyl tin dilaurate (DBTDL) as a catalyst to form a polyester urethane. Polyester urethane has tensile strength of 51-59 MPa and elongation at fracture of 369-439%. FTIR and XRD were used to confirm the formation and structure of the polymer. Hydrolytic degradation was studied in different alkali solutions and in saline water. In order to assess the cellular response of this material, cytotoxicity analysis was carried out against the cell line.
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