Journal
STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES I
Volume 1317, Issue -, Pages 84-91Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12440
Keywords
vitamin D; B cell function; autoimmune diseases; regulatory B cell; interleukin-10
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Vitamin D seems to be implicated in the pathophysiology of autoimmune disorders as a natural immune modulator. Beneficial effects of vitamin D have been associated with different cells of the immune system; however, thus far, B cells seem to be somewhat neglected. In this paper, we describe the possible direct effects of vitamin D on B cells, with a focus on antibody production and the more recently identified regulatory B (B-reg) cells. B cells upregulate the vitamin D receptor (VDR) upon activation. Furthermore, due to regulated expression of the metabolizing enzymes CYP27B1 and CYP24A1, B cells have the potential to control the local availability of active vitamin D. B cells, therefore, may participate in vitamin D-mediated immune homeostasis, including plasma cell generation. Whether or not other B cell subsets, such as B-reg cells, are equally responsive to vitamin D remains to be established.
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