Journal
YEAR IN IMMUNOLOGY: MYELOID CELLS AND INFLAMMATION
Volume 1319, Issue -, Pages 1-18Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12393
Keywords
macrophage; monocyte; hematopoesis
Categories
Funding
- US National Institutes of Health (NIH) [R01-AI084880, P50-CA086355, U54-CA126515, R01-HL096576, R01-HL095629, R01-HL095612, R56-AI104695]
Ask authors/readers for more resources
Essential protectors against infection and injury, macrophages can also contribute to many common and fatal diseases. Here, we discuss the mechanisms that control different types of macrophage activities in mice. We follow the cells' maturational pathways over time and space and elaborate on events that influence the type of macrophage eventually settling a particular destination. The nature of the precursor cells, developmental niches, tissues, environmental cues, and other connecting processes appear to contribute to the identity of macrophage type. Together, the spatial and developmental relationships of macrophages compose a topo-ontogenic map that can guide our understanding of their biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available