Journal
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
Volume 6, Issue 2, Pages 231-244Publisher
TAYLOR & FRANCIS AS
DOI: 10.1586/14737159.6.2.231
Keywords
biosensor; cancer; imaging; immunohistochemistry; in vivo; multiplex; nanotechnology; quantum dot; toxicity
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Funding
- NCI NIH HHS [U54 CA119338, R01 CA108468] Funding Source: Medline
- NIGMS NIH HHS [P20 GM072069, R01 GM60562] Funding Source: Medline
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In the pursuit of sensitive and quantitative methods to detect and diagnose cancer, nanotechnology has been identified as a field of great promise. Semiconductor quantum dots are nanoparticles with intense, stable fluorescence, and could enable the detection of tens to hundreds of cancer biomarkers in blood assays, on cancer tissue biopsies, or as contrast agents for medical imaging. With the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types, and has identified new cancer-specific markers. Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging.
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