Journal
CELL CYCLE
Volume 5, Issue 5, Pages 512-518Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.5.2538
Keywords
Akt signaling; angiogenesis; endothelial cell; thrombospondin; collagen; laminin; vascular permeability
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Funding
- NHLBI NIH HHS [R01 HL071625, HL071625] Funding Source: Medline
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Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.
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