Journal
CANCER GENE THERAPY
Volume 13, Issue 3, Pages 318-325Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cgt.7700894
Keywords
genetic immunization; dendritic cells; melanoma; T cells; TRP2
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Optimal strategies for antigen-specific melanoma vaccination are currently being defined in experimental mouse models. Using a single H2-K-b-binding peptide epitope derived from the melanosomal enzyme tyrosinase-related protein 2 (TRP2) in C57BL/6 mice, we show that adenovirus-transduced dendritic cells (DC) are clearly superior to peptide-pulsed DC for the induction of CD8+ T cells and antimelanoma immunity. Vaccine efficacy strictly depended on the presence of linked CD4+ T-cell help during the priming but not the effector phase of the immune response. These results provide important information for the translation of melanoma vaccine strategy in future clinical applications.
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