Journal
GLYCOBIOLOGY OF THE IMMUNE RESPONSE
Volume 1253, Issue -, Pages 1-15Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06492.x
Keywords
glycobiology; glycoimmunology; glycans; lectins; C-type lectins; siglecs; galectins
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI079756] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM082916] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD004225] Funding Source: NIH RePORTER
- NIAID NIH HHS [R21 AI079756, AI079756] Funding Source: Medline
- NIGMS NIH HHS [R01 GM082916, GM082916] Funding Source: Medline
- NIH HHS [DP2 OD004225, OD004225] Funding Source: Medline
Ask authors/readers for more resources
Unlike their protein roommates and their nucleic acid cousins, carbohydrates remain anenigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function are tied is the nontemplate nature of their synthesis and the resulting heterogeneity. The goal of this collection of expert reviews is to highlight what is known about how carbohydrates and their binding partners-the microbial (non-self), tumor (altered-self), and host (self)-cooperate within the immune system, while also identifying areas of opportunity to those willing to take up the challenge of understanding more about how carbohydrates influence immune responses. In the end, these reviews will serve as specific examples of how carbohydrates are as integral to biology as are proteins, nucleic acids, and lipids. Here, we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs, and galectins) and their contributions to the biology of immune responses in physiologic and pathologic settings.
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