Journal
BARRIERS AND CHANNELS FORMED BY TIGHT JUNCTION PROTEINS II
Volume 1258, Issue -, Pages 34-42Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06526.x
Keywords
tight junction; myosin light chain kinase; TNF-alpha; inflammatory bowel disease
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Funding
- NCI NIH HHS [P30 CA014599, P30CA14599] Funding Source: Medline
- NCRR NIH HHS [UL1RR024999, UL1 RR024999] Funding Source: Medline
- NIDDK NIH HHS [R01DK68271, R01 DK061931, R01 DK061931-12, R01 DK068271, P01DK067887, P01 DK067887, R01 DK068271-08, R01DK61931] Funding Source: Medline
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Dynamic regulation of paracellular permeability is essential for physiological epithelial function, while dysregulated permeability is commonindisease. The recent elucidationof themolecular compositionof the epithelial tight junction complex has been accompanied by characterization of diverse intracellular mediators of paracellular permeabiltiy. Myosin light chain kinase (MLCK), which induces contraction of the perijunctional actomyosin ring throughmyosin II regulatory light chain phosphorylation, has emerged as a key regulator of tight junction permeability. Examination of the regulation and role of MLCK in tight junction dysfunction has helped to define pathological processes and characterize the role of barrier loss in disease pathogenesis, and may provide future therapeutic targets to treat intestinal disease.
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