An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study

Objective: To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs Design and setting: Cohort, multicentre, observational study of 198 ICUs in 24 European countries. patients and interventions: All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria. Results: During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased. Conclusions: Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.