Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 172, Issue 1-2, Pages 59-65Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.11.001
Keywords
interleukin-18; immobilization stress; adrenal gland; adrenalectomy; HPA axis
Categories
Ask authors/readers for more resources
The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy, These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress. (C) 2005 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available