Journal
ADVANCES AGAINST ASPERGILLOSIS II
Volume 1273, Issue -, Pages 68-73Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06821.x
Keywords
reactive oxygen species; phosphoinositide 3-kinase; beta(2)-integrin; antifungal immunity
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000M211, BBS/E/B/0000C218, BBS/E/B/000C0411] Funding Source: researchfish
- Medical Research Council [MC_U105170648, G0600840] Funding Source: researchfish
- BBSRC [BBS/E/B/0000C218, BBS/E/B/0000M211, BBS/E/B/000C0411] Funding Source: UKRI
- MRC [G0600840, MC_U105170648] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000M211, BBS/E/B/000C0411, BBS/E/B/0000C218] Funding Source: Medline
- Medical Research Council [G0600840, MC_U105170648] Funding Source: Medline
Ask authors/readers for more resources
Upon infection of the respiratory system with the fungus Aspergillus fumigatus various leukoctytes, in particular neutrophils, are recruited to the lung to mount an immune response. Neutrophils respond by both phagocytosing conidia and mediating extracellular killing of germinated, invasive hyphae. Of paramount importance to an appropriate immune response is the neutrophil NADPH oxidase enzyme, which mediates the production of various reactive oxygen species (ROS). This is evidenced by the acute sensitivity of both oxidase-deficient humans and mice to invasive aspergillosis. Herein we briefly review the mechanisms and functions of oxidase activation and discuss our recent work identifying at least some of the important players in hyphal-induced oxidase activation and neutrophil function. Among these we define the phosphoinositide 3-kinase enzyme and the regulatory protein Vav to be of critical importance and allude to a kinase-independent role for Syk.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available