Journal
ENVIRONMENTAL STRESSORS IN BIOLOGY AND MEDICINE
Volume 1259, Issue -, Pages 47-53Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06532.x
Keywords
cigarette smoke; sarcopenia; MAPKs; NF-kappa B; MAFbx/atrogin-1; MuRF1
Categories
Funding
- Rappaport Institute
- Krol Foundation in Barnegat, New Jersey
- Myers-JDC-Brookdale Institute of Gerontology and Human Development
- ES-HEL, the association for planning and development of services for the aged in Israel
Ask authors/readers for more resources
Sarcopenia, the age-related loss of muscle mass and strength, is a multifactorial impaired state of health. Lifestyle habits such as physical activity and nutrition have a major impact on sarcopenia progression. Several epidemiological studies have also shown an association between cigarette smoking and increased levels of sarcopenia in elderly longtime smokers. Clinical, in vivo, and in vitro studies have tried to investigate the mechanism behind exposure to cigarette smoke (CS) and the subsequent effects on skeletal muscles. The aim of this review is to present a cellular model of CS-induced skeletal muscle protein breakdown based on recent studies dealing with this issue and to propose new potential research directions that may explain the effects of exposure to CS on skeletal muscle integrity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available